The Karela extract is traditionally used as vegetable insulin as it might have antioxidant and antidiabetic properties. Its antidiabetic effect is tested in both animals and humans. When tested in an animal model, the entire plant, including fruit pulp and seed, showed potential antidiabetic property.

Bitter gourd eating on a regular basis improves skin, hair, and cancer issues. It also aids in the improvement of blood circulation. Karela is high in vitamin A, which helps to prevent cataracts and improves vision. It even helps to brighten dark circles.